modified from Fitzpatrick's dermatology 8th
除了課本的圖要念，希望大表一張就夠
chemokine真是考試噩夢
Receptor 細胞來源 作用 重要ligand
CCR 1
|
T,B,NK,DC,Mo
|
DC和monocyte移動
T cell表現多(因IL-2)
|
MIP-1a (CCL3)
RANTES(5) MCP-3(7)
|
CCR 2
|
T,Mo
|
T cell移動
LC 到epidermis
Skin fibrosis (MCP-1)
|
MCP-1 (2)
MCP-3,4 (13)
|
CCR 3
|
Th2,K,Eo,Ba
|
Th2移動 allergic immune cell
|
Eotaxin (11)
|
CCR 4
|
T
|
Th2>Th1, CLA memory T多
Atopic (TRAC在角質細胞)
|
TARC (17)
MDC (22)
|
CCR 5
|
T,Mo,DC
|
Th1, HIV-1
|
|
CCR 6
|
T,DC,B
|
Psoriasis ,Memory T
|
|
CCR 7
|
T,DC,B
melanoma
|
Naïve/central memory T去LN
Mature DC去lymph
|
SLC(21)
ELC(19)
|
CCR 9
|
T, melanoma
|
Small bowel meta
|
Thymus expressed cytokine (25)
|
CCR 10
|
T,melanoma
|
T-cell去epidermis
Melanoma在皮膚survive
|
CTACK (27)
|
CXCR 1,2
|
Neu,NK,endothelium
melanoma
|
招喚neutrophil(psoriasis表皮), 血管新生, melanoma
growth factor
|
|
CXCR 3
|
T
|
Th1
CTCL被召喚去Epidermis
|
|
CXCR 4
|
T,DC,Endothelium
melanoma
|
Major HIV-1
血管形成, melanoma去肺
|
SDF-1A,B (CXCL12)
|
CX3CR 1
|
T,NK,Mo,mast cell
|
發炎細胞Adhesion到endothelium
|
Fractalkine (CX3CL1)
|
重要疾病
Psoriasis: CCR6, CXCR1/2
Th1: CCR5, CXCR3
Th2: CCR3, CCR4
Fibrosis: CCR2
